14 December 2017

C4X Discovery Holdings plc: Full year results for the year ended 31 July 2017


14 December 2017 – C4X Discovery Holdings plc (AIM: C4XD), a pioneering drug discovery company, today announces its full year results for the year ended 31 July 2017.

Financial highlights

  • Completion of a £5.0 million fundraise in September 2016 through the placing of 4,901,961 new ordinary shares in the capital of the Company (“Ordinary Shares”) at a price of 102 pence per Ordinary Share, as reported in the 2016 annual report.
  • Completion of a £7.0 million fundraise in March 2017 through the placing of 8,235,294 new Ordinary Shares with existing and new investors at a price of 85 pence per Ordinary Share.
  • Year-end cash of £6,031,000 (2016: £1,328,000) remains on the balance sheet following the £5 million and £7 million raised via placings.
  • R&D expenditure rose 16% to £6,100,000 (2016: £5,239,000) reflecting both the increase in drug discovery activity and the continued development of lead drug candidates towards commercialisation.


Operational highlights

Corporate highlights


  • The Board is committed to the delivery of C4X Discovery Holding plc’s (“C4XD’s”) vision to become the world’s most productive drug discovery engine by exploiting cutting-edge technologies to design and create best-in-class small molecule candidates targeting a range of high value therapeutic areas.
  • C4XD focusses on generating a high value pre-clinical asset portfolio that will drive revenue through early stage licensing deals with the pharmaceutical industry. Existing fee-for-service agreements have been discontinued during the current financial year.


  • The Company continues to enhance its core state-of-the-art target identification and drug design capabilities through strategic partnerships:
    • A multi-target risk-sharing alliance with Evotec AG (“Evotec”) was announced in September 2016.

Discovery Engine progress

  • C4XD’s proprietary drug asset portfolio has grown from three programmes in 2014 to eight programmes across a number of therapeutic areas.
  • Disease areas of focus are inflammation, neurodegeneration, and opportunistic areas (e.g. immuno-oncology, addiction and diabetes).


Senior appointments

  • Brad Hoy, Chief Financial Officer, and Dr Craig Fox, Chief Scientific Officer, were appointed to the Board of Directors in November 2016.


Post-period end

  • New pre-clinical data on C4XD’s leading Orexin-1 antagonist programme were presented at Neuroscience 2017 in November in Washington, DC.

“This has been an important year for C4XD in positioning us to achieve our ambitions in drug discovery and deliver value for our shareholders. We have progressed our pipeline towards commercialisation, identified new drug targets and discovery programmes and raised the capital required to support our strategy. “We have also seen high levels of pre-clinical partnering interest for our lead programme Orexin-1 to treat addiction and have entered into late stage commercial discussions. During the fundraise in March 2017 we stated that we fully expected to complete our first commercial deal within 12 months of that date. We believe and understand that this is a crucial element of successful implementation of our business model. We continue to believe that this important milestone will be met. Our goal is to become a self-sustaining business and I am confident we will see significant progress in the coming months in delivering on the potential of our model.”

Dr Clive Dix

CEO of C4X Discovery

This announcement contains inside information for the purposes of Article 7 of Regulation (EU) No 596/2014 (MAR).




For further information, please contact:


C4X Discovery Holdings plc

Clive Dix, Chief Executive Officer                                                                                                     07801 865 803

Panmure Gordon (UK) Limited (NOMAD and Broker)

Freddy Crossley (Corporate Finance)                                                                                               020 7886 2500

Tom Salvesen (Corporate Broking)

Consilium Strategic Communications

Mary-Jane Elliott, Chris Gardner, Matthew Neal, Melissa Gardiner                                                       0203 709 5700



About C4X Discovery

C4X Discovery aims to become the world’s most productive drug discovery engine by exploiting cutting edge technologies to design and create best-in-class small-molecule candidates targeting a range of high value therapeutic areas. The company’s goal is to drive returns through early-stage revenue-generating deals with the pharmaceutical industry.

C4X Discovery has a state-of-the-art suite of proprietary technologies across the drug discovery process. The company’s innovative DNA-based target identification platform (Taxonomy3®) utilises human genetic datasets to identify novel patient-specific targets leading to greater discovery productivity and increased probability of clinical success. This is complemented by C4XD’s novel drug design platform which comprises two innovative chemistry technologies, Conformetrix and Molplex, that combine 4D molecular shape analyses (based on experimental data) with best-in-class computational chemistry. This provides new and unprecedented insight into the behaviour of drug molecules, enabling the production of potent selective compounds faster and more cost effectively than the industry standard.

C4X Discovery is advancing its in-house pipeline in addiction, diabetes and inflammation with a number of new drug candidates identified and further progress made towards the clinic. In selecting new targets C4X Discovery will focus on the high-value disease areas of inflammation and neurodegeneration, and will continue to maximise value from opportunistic areas, for example, immuno-oncology, addiction, and diabetes.

The Company was founded as a spin-out from the University of Manchester. It has a highly experienced management team and Board who have delivered significant value creation within the healthcare sector historically and have enabled C4XD to reach multiple value inflexion points since IPO. For additional information please go to: www.c4xdiscovery.com.

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