06 September 2017



LOXL2 Inhibitor Update


- Successful completion of LOXL2 preclinical studies

- Phase I trial on track to commence in Q4 2017


Southampton, UK – 6 September 2017: Synairgen (LSE: SNG), the respiratory drug discovery and development company, is pleased to announce that, following the successful completion of preclinical pharmacology and toxicology studies, a compound from its anti-fibrotic Lysyl Oxidase type 2 (LOXL2) inhibitor programme, PXS-5382A, is being prepared to commence Phase I clinical development.


PXS-5382A is being developed in partnership with Pharmaxis (ASX: PXS) to target the fatal lung disease idiopathic pulmonary fibrosis (IPF) and other fibrotic conditions including non-alcoholic steatohepatitis (NASH), kidney fibrosis and heart fibrosis.


Synairgen will progress PXS-5382A through the Phase I trial, the results of which are expected mid-2018. Thereafter Synairgen and Pharmaxis plan to out-license PXS-5382A to a suitable partner to fully realise the commercial value of this compound given the potential size and number of indications it could address.

“We believe PXS-5382A is a very valuable candidate with potential applications in a number of fibrotic conditions including lung, liver, cardiac and kidney fibrosis. These diseases represent areas of high unmet medical need and consequently present very substantial market opportunities. “The effect of this novel inhibitor across different model types is very exciting, with the latest supporting data suggesting that PXS-5382A can significantly reduce lung fibrosis and therefore has the potential to improve lung function in severely ill patients. These data build on the encouraging results seen to date and further support the rationale behind bringing this promising inhibitor to clinic. “Based on PXS-5382A’s potential across a number of disease areas and the promising data seen to date, we have received significant interest from companies looking to license the programme for multiple indications. We look forward to progressing these discussions as PXS-5382A advances through the clinic. This outcome has been the result of a successful collaboration with Pharmaxis, through the combination of their expertise in small molecule drug development and Synairgen’s expertise in translational research in lung diseases.”

Richard Marsden

CEO of Synairgen

LOXL2 is a pro-fibrotic enzyme believed to play a significant role in the collagen cross-linking formation process in fibrotic diseases such as NASH, cardiac fibrosis, kidney fibrosis and IPF; all of which are areas of high unmet need that could have substantial potential. The LOXL2 inhibitor PXS-5382A is a potent and selective inhibitor of LOXL2 and has consistently been shown to significantly reduce and inhibit cross-linking formation in in vitro and in vivo models of lung, liver and cardiac fibrosis. These findings have been the subject of presentations at numerous international scientific conferences and more data will be presented at similar upcoming events as the Phase I trial proceeds.


The Company continues to analyse the data from the INEXAS trial and expects to make a further announcement regarding the potential of its inhaled interferon-beta drug (SNG0010) shortly.




For further enquiries, please contact:


Synairgen plc

Richard Marsden, Chief Executive Officer

John Ward, Finance Director

Tel: + 44 (0) 23 8051 2800



Geoff Nash, James Thompson (Corporate Finance)

Stephen Norcross, Simon Johnson (Corporate Broking)

Tel: + 44 (0) 20 7220 0500


Consilium Strategic Communications (Financial Media and Investor


Mary-Jane Elliott / Philippa Gardner / Laura Thornton


Tel: +44 (0) 20 3709 5701



Notes for Editors

About Synairgen

Synairgen is a respiratory drug discovery and development company founded by University of Southampton Professors Stephen Holgate, Donna Davies and Ratko Djukanovic. The business, focused primarily on asthma and COPD, uses its differentiating human biology BioBank platform and world-renowned international academic KOL network to discover and develop novel therapies for respiratory disease. Leveraging its scientific and clinical facilities at Southampton General Hospital, the Company uses in vitro and ex vivo models to progress opportunities into clinical development. The BioBank of human samples is used in these models to increase confidence in the likelihood of successful drug development. Core to Synairgen’s business strategy is the realisation of value via licensing transactions. In August 2015 the Company entered into a collaboration with Pharmaxis to develop an oral LOXL2 inhibitor to reduce fibrosis in patients with idiopathic pulmonary fibrosis (IPF). Synairgen is quoted on AIM (LSE: SNG). For more information about Synairgen, please see www.synairgen.com.


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